RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
let-7d
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
qRT-PCR; GO analysis; etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension
Year
2013
Function
"Eighteen miRNAs were differentially expressed in PASMCs from CTEPH patients, including 12 upregulated miRNAs and 6 downregulated miRNAs; Among the latter, let-7d decreased 0.58-Fold in CTEPH patients. Let-7d could inhibit the proliferation of PASMCs through upregulation of p21. In conclusion, PASMCs in CTEPH patients have an aberrant miRNA profile and reduced let-7d, which could promote PASMC proliferation and may be involved in the pathogenesis of CTEPH."